Programmed cell death regulation: basic mechanisms and therapeutic opportunities
نویسندگان
چکیده
منابع مشابه
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T HE terms programmed cell death (PCD) 1 and apoptosis are often used interchangeably to describe a mechanism of cellular demise that is believed to play an important role in a wide variety of physiological situations, and that when dysregulated can contribute to the pathogenesis of many diseases ranging from cancer to AIDS. Recently, the bcl-2 gene has emerged as a critical regulator of PCD in...
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Programmed cell death (PCD) is a basic biological phenomenon that plays an important role during development, preservation of tissue homeostasis, and elimination of damaged cells. Several nomenclature systems have been proposed to classify PCD. One widely accepted system describes three major morphologies of programmed cell death, and classifies PCD as type I, apoptosis; type II, autophagy; and...
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T HE terms programmed cell death (PCD) 1 and apoptosis are often used interchangeably to describe a mechanism of cellular demise that is believed to play an important role in a wide variety of physiological situations, and that when dysregulated can contribute to the pathogenesis of many diseases ranging from cancer to AIDS. Recently, the bcl-2 gene has emerged as a critical regulator of PCD in...
متن کامل[Mechanisms of programmed cell death of effector T lymphocytes].
T cell adequate function is critical for defense against pathogens. Transient disruption of T cell homeostasis occurs when primarily naive cells undergo antigen-driven expansion and acquire effector functions. Effector T cells then either undergo programmed cell death (PCD, it occurs usually as massive apoptosis during the contraction phase of the immune response) or survive to become memory ce...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2000
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401849